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When onscreen chemistry transcends the screen, it's only fitting that close friendships blossom. These costars are BFF in real life as well when they're playing their roles.

Julia Lechner
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1 of 26 Helen Sloan/HBO

BFF on and off the screen

It's an actor's job to play make believe, yet sometimes that on-screen chemistry transcends the show. Find out which TV stars are real-life besties.

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KJ Apa and Cole Sprouse

In the hit teen drama Riverdale, Apa and Sprouse play best friends from the opposite side of the tracks. The two often post hilarious photos of one another and seem just as close as their characters.

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Lili Reinhart and Camila Mendes

There's just something about Riverdale that makes costars BFFs. Reinhart and Mendes play Betty and Veronica, best friends with a fair amount of drama. Yet it's nothing but love between these two in real life.

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Sophie Turner and Maisie Williams

They play sisters with hard lives on Game of Thrones but in reality the two are often seen side by side in much better spirits. Turner and Williams are so close that Williams will be a bridesmaid in Turner's wedding to Joe Jonas.

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Jennifer Aniston and Courteney Cox

The main cast of Friends all generally got along with each other, but Aniston and Cox are arguably the closest.

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Jared Padalecki and Jensen Ackles

These two babes have been starring on Supernatural for over a decade, and fans have watched them become super close friends on and off screen.

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Michelle Williams and Busy Philips

Williams and Philips met on the iconic teen drama Dawson's Creek. They're often each other's dates to awards shows and Philips recently flew to be by Williams' side on the anniversary of Heath Ledger's death.

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Ashley Tisdale and Vanessa Hudgens

They may not have been BFF in Disney's TV movie High School Musical, but Tisdale and Hudgens are super close. You could even say they're "all in this together."

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Ashley Benson and Shay Mitchell

Pretty Little Liars was full of backstabbing frenemies, but there's nothing fake about these two. Benson and Mitchell play friends on the dramatic teen show and are super close in real life as well.

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Mindy Kaling and B.J. Novak

Many people have shipped Kaling and Novak romantically since they graced television screens as Ryan and Kelly on The Office. Though they're not together, the pair remain besties.

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Jenna Fischer and Angela Kinsey

Although Pam and Angela on The Office weren't quite BFFs, these actresses are closer than ever.

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Chris Pratt and Aubrey Plaza

They played the delightful couple of April and Andy on Parks and Recreation for several years, and these two are best buds.

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Dylan O'Brien and Tyler Posey

They were both baby-faced actors in season one of Teen Wolf, but we saw them grow over the course of the series. They're not shy about their bromance.

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Mariska Hargitay and Chris Meloni

Being on a show as intense as Law & Order: SVU can draw you closer to your costars. Hargitay and Meloni have a friendship that many loyal SVU fans are obsessed with.

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Tina Fey and Amy Poehler

The two comedians were close long before they were famous. Their comedic chemistry on stage is just as strong as their chemistry off of it.

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Andrea Barber and Candace Cameron Bure

The world fell in love with the friendship between D.J. Tanner and Kimmy Gibbler on Full House. Their bond went beyond the screen and has lasted decades.

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Donald Faison and Zach Braff

Faison and Braff played best friends and coworkers on Scrubs but the bromance was strong in real life. J.D. and Turk forever.

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Emma Roberts and Lea Michele

The pair are enemies on Scream Queens, but these two are inseparable. They go shopping, attend events, and comment adorable things on each other's posts.

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Dave Coulier, John Stamos and Bob Saget

It only makes sense that the men of Full House are actually buds. While they don't live together like their characters do on the show, they're still great pals.

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Colton Haynes and Holland Roden

Teen Wolf stars Colton Haynes and Holland Roden are super close. Roden recently attended Haynes' wedding, and they often post about each other on Instagram.

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JWoww and Snooki

There was a ton of drama on MTV's The Jersey Shore, but reality stars JWoww and Snooki formed a close friendship.

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Neil Patrick Harris and Cobie Smulders

This friendship is legen... wait for it... dary. The two played friends turned romantic partners in How I Met Your Mother. Barney and Robin forever.

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Norman Reedus and Jeffrey Dean Morgan

Jeffrey Dean Morgan may play one of the most horrific villians in The Walking Dead universe, but outside of the zombie TV show, Reedus and Morgan have a strong bromance.

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Selena Gomez and David Henrie

They played TV siblings on Wizards of Waverly Place, and have remained close since. Gomez, along with the rest of the cast of Disney's hit show, recently attended Henrie's wedding.

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Taylor Schilling and Laura Prepon

Their relationship in Orange Is the New Black is a complete rollercoaster, but Schilling and Prepon are a match made in friendship heaven.

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Nina Dobrev, Candice King and Kat Graham

The Vampire Diaries has ended, but this trio's friendship is eternal.