- As a youth appeared in theater productions with Chloë Sevigny, who also at times babysat him and his sister.
- Didn't like being called Chris so he dropped Chris from his first name and went by Topher.
- Wanted to be a pro tennis player but an ankle injury turned his attention to acting.
- Was discovered while performing in a high-school production of A Funny Thing Happened on the Way to the Forum by producers Bonnie and Terry Turner, whose daughter was also in the cast.
- Big break came in 1998 when the Turners created That '70s Show and cast him in the lead role of Eric Forman.
- Has appeared in three movies directed by Steven Soderbergh (Traffic, Ocean's Eleven, Ocean's Twelve).
- National Board of Review honored him in 2004 with their Best Breakthrough Performance by Actor award for In Good Company and P.S.
- Cowrote the script for Take Me Home Tonight (2011), an '80s-themed film in which he also played the lead character.
- 2000, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Winner
- Pat Grace — Mother
- James Knight Newman — Godchild
- John Grace — Father
- Jennifer Grace — Sister
- Ashley Hinshaw — Wife
- Attended University of Southern California, Los Angeles, California, United States