- First regular TV role came with Baby Boom (1988-89), an adaptation of the 1987 Diane Keaton feature.
- Began her stand-up career in Manhattan, along with then-fledgling comedians Chris Rock, Mario Cantone and Colin Quinn.
- Early big-screen roles included Tom Hanks comedy Punchline (1988) and kiddie sequel Teenage Mutant Ninja Turtles II (1991).
- Cast without an audition in Larry David's improvisational sitcom Curb Your Enthusiasm after David watched her perform at the Friar's Club Roast of Jerry Stiller.
- Appeared in an off-Broadway production of The Vagina Monologues in 2000.
- Hosted Bravo's reality-competition series Better Half, in which couples try to teach their mates how to do their jobs.
- Does not eat meat.
- 2015, Critics' Choice Television Awards — Best Guest Performer in a Comedy Series: Nominee
- 2017, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Comedy Series: Nominee
- 2009, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Comedy Series: Nominee
- 2005, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Comedy Series: Nominee
- Jimmy Harder — Husband
- Leonard Essman — Father
- Zora Essman — Mother
- Purchase College, Purchase, New York, United States (BA, 1977)