- Is of the third generation of a show-business family; her grandfather, Harry Crane, wrote for the classic 1950s sitcom Honeymooners.
- Made her acting debut in a television commercial at age 6.
- Stage name comes from the last name of her half-siblings, Melissa Gilbert and Jonathan Gilbert.
- Studied art and photography at Yale University during the filming of the final several seasons of the sitcom Roseanne in the mid 1990s.
- Joined the cast of The Big Bang Theory in 2007 as the love interest of Johnny Galecki, who had played her husband on Roseanne 10 years earlier.
- 1993, Emmy — Outstanding Supporting Actress in a Comedy Series: Nominee
- 1994, Emmy — Outstanding Supporting Actress in a Comedy Series: Nominee
- 1993, Independent Spirit Awards — Best Supporting Female: Nominee
- Linda Perry — Wife
- Patrice Graves — Half Sister
- Julia Crane — Grandmother
- Harry Crane — Grandfather
- Joseph Abeles — Half Brother
- Allison Adler — Ex-significant Other
- Warren Cowan — Stepfather
- Sawyer Gilbert-Adler — Daughter
- Barbara Crane — Mother
- Melissa Gilbert — Half Sister
- Levi Hank Gilbert-Adler — Son
- Jonathan Gilbert — Half Brother
- Harold Abeles — Father
- Rhodes Emilio Gilbert Perry — Son
- Yale University, New Haven, Connecticut, United States (BA in Art, 1997)
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