- Named for great-great-aunt and opera soprano Adelina Patti.
- Made stage debut tap dancing at the age of 4 and later performed with her teenage twin brothers as the LuPone Trio.
- Breakout role was her Tony Award-winning performance of Eva Peron in Andrew Lloyd Webber's hit Evita in 1979.
- Became the first American actress to win an Olivier Award (she received it for creating the role of Fantine in the Royal Shakespeare Company production of Les Miserables).
- Met husband Matthew while working on the TV movie LBJ: The Early Years in 1986; married him on the stage of the Vivian Beaumont Theater at Lincoln Center two years later.
- Originated the role of Norma Desmond in the London production of Lloyd Webber's musical Sunset Boulevard and was under contract to transfer to Broadway; when the composer plucked Glenn Close from the Los Angeles production to open the show in New York, LuPone threatened to sue and won close to $1 million.
- Stopped the show and broke character near the end of her Tony Award-winning run in Gypsy to chastise an audience member who was taking photographs during the performance.
- 1988, Tony — Actress (Musical): Nominee
- 1998, Emmy — Outstanding Guest Actress in a Comedy Series: Nominee
- 2017, Tony — Actress (Musical): Nominee
- 2008, Tony — Actress (Musical): Winner
- 1980, Tony — Actress (Musical): Winner
- 2006, Tony — Actress (Musical): Nominee
- 2015, Critics' Choice Awards — Best Guest Actor/Actress in a Drama Series: Nominee
- 1976, Tony — Actress (Featured Role--Musical): Nominee
- 2008, Grammy — Best Classical Album: Winner
- 2008, Grammy — Best Opera Recording: Winner
- 2011, Tony — Actress (Featured Role--Musical): Nominee
- William LuPone — Brother
- Robert LuPone — Brother
- Orlando Joseph LuPone — Father
- Angela Louise LuPone — Mother
- Kevin Kline — Ex-significant Other
- Joshua Luke Johnston — Son
- Matthew Johnston — Husband
- The Juilliard School, New York, New York, United States (BFA in Drama, 1972)
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