- Has performed as a stand-up comedian.
- Was denied entrance to the University of Southern California's film school five times.
- Put on 25 pounds while shooting his Oscar-nominated 2004 documentary Super Size Me, which chronicled his 30-day all-McDonald's diet and its effects.
- Super Size Me was made for $65,000 out of his own pocket.
- Made his on-screen acting debut in the 2007 straight-to-video slasher flick Drive Thru, about a fast-food mascot who goes on a killing spree.
- In 2010, directed The Simpsons 20th Anniversary Special -- In 3D! On Ice!
- His 2010 documentary The Greatest Story Ever Sold examines and was funded by product placement.
- Host and producer of the CNN series Inside Man, which explores American cultural traditions and examines pressing issues such as marijuana, gun control and immigration.
- Has traveled to all 50 states.
- Has a folder that holds every rejection letter he's ever received.
- 2005, Writers Guild Awards — Documentary Screenplay: Winner
- 2010, Emmy — Outstanding Nonfiction Special: Nominee
- 2004, Oscar — Best Documentary (Feature): Nominee
- 2004, Sundance Film Festival — Directing Award: Documentary: Winner
- Laken James Spurlock — Son
- Phyllis Spurlock — Mother
- Craig Spurlock — Brother
- Alexandra Jamieson — Ex-wife
- Ben Spurlock — Father
- Sara Bernstein — Wife
- Barry Spurlock — Brother
- New York University, Tisch School of the Arts, New York, New York, United States (BFA, Kanbar, Film and TV, 1994)