- Appeared in commercials as a child; played Gilda Radner's son in a British Columbia Hydroelectric ad at age 10.
- In the eighth grade, wrote an essay about Saturday Night Live producer Lorne Michaels.
- Joined the Second City comedy troupe right after high school.
- Named and modeled his Saturday Night Live "Coffee Talk" character Linda Richman after his then mother-in-law.
- Was inspired to create Austin Powers: International Man of Mystery after hearing Burt Bacharach's "The Look of Love" on the radio. Wrote the script in three weeks.
- Originally voiced Shrek with a Canadian accent before trying a Scottish brogue that "just felt right."
- Awarded a star on the Canadian Walk of Fame; and has a street named after him (Mike Myers Drive) in Scarborough, Ontario.
- 1989, Emmy — Outstanding Writing in a Variety or Music Program: Winner
- 1994, Emmy — Outstanding Individual Performance in a Variety or Music Program: Nominee
- 1990, Emmy — Outstanding Writing in a Variety or Music Program: Nominee
- 2009, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Winner
- Eric Myers — Father
- Peter Myers — Brother
- Robin Ruzan — Ex-wife
- Paul Myers — Brother
- Alice Myers — Mother
- Spike Myers — Son
- Kelly Tisdale — Wife
- Sunday Molly Myers — Daughter
- Paulina Kathleen Myers — Daughter