- His parents were Yiddish-speaking Jewish immigrants who escaped from Stalinist Russia.
- Appeared in his first play, Hansel and Gretel, at the age of 8.
- After a two-year stint in the Army, enrolled at California's Pasadena Playhouse.
- His appearance in an episode of the series The Lieutenant caught the eye of Star Trek creator Gene Roddenberry, who cast him in the role of Mr. Spock.
- Directed the big-screen outings Star Trek III: The Search for Spock (1984) and Star Trek IV: The Voyage Home (1986), as well as the hit comedy Three Men and a Baby.
- Created the "live long and prosper" Vulcan salute, based on a Jewish blessing he'd seen as a child.
- Received a star on the Hollywood Walk of Fame in 1985.
- Has published collections of poetry and two autobiographies.
- 1967, Emmy — Outstanding Performance by an Actor in a Supporting Role in a Drama: Nominee
- 1982, Emmy — Outstanding Supporting Actor in a Limited Series or Special: Nominee
- 1969, Emmy — Outstanding Continued Performance by an Actor in a Supporting Role in a Series: Nominee
- 1968, Emmy — Outstanding Performance by an Actor in a Supporting Role in a Drama: Nominee
- Melvin Nimoy — Brother
- Dora Nimoy — Mother
- Max Nimoy — Father
- Sandi Zober — Ex-wife
- Adam Nimoy — Son
- Aaron — Stepson
- Julie — Daughter
- Susan Bay — Wife
- Attended Boston College, Boston, Massachusetts, United States; Antioch College, Austin, Texas, United States (MA in Education); attended University of California, Los Angeles, California, United States