- Encouraged to pursue acting by older brother Rob's success and by Martin Sheen, who was the family's neighbor when they moved to California during his childhood.
- Took inspiration for his Emmy-winning role as HIV-positive teen Jesse McKenna in the series Life Goes On from the real-life struggle and AIDS-related death of his former manager Tim Wood.
- Directed his then-wife Hilary Swank in the 2000 short film The Audition and again in the 2002 short The Space Between.
- 1993, Emmy — Outstanding Supporting Actor in a Drama Series: Winner
- Mabel Painter Lowe — Daughter
- Rob Lowe — Brother
- Barbara Wilson — Mother
- Steve Wilson — Stepfather
- Justin Lowe — Half Brother
- Chuck Lowe — Father
- Hilary Swank — Ex-wife
- Micah Dyer — Half Brother
- Nixie Barbara Lowe — Daughter
- Fiona Hepler Lowe — Daughter
- Kim Painter — Wife
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