- Along with her five siblings, used props, wigs and disguise kits to put on shows for the family in their living room and backyard.
- Coauthored a number of plays with her brother, humorist David Sedaris, winning Obie and Drama Desk awards.
- Provided her voice for the audio versions of her brother David's books, Barrel Fever, Naked and Holidays on Ice.
- Former member of the Second City comedy troupe in Chicago.
- Is a best-selling author; published I Like You: Hospitality Under the Influence in 2006 and Simple Times: Crafts for Poor People in 2010.
- Runs a cupcake-and-cheeseball business out of her NYC home.
- David Sedaris — Brother
- Lou Sedaris — Father
- Lisa Sedaris — Sister
- Tiffany Sedaris — Sister
- Paul Sedaris — Brother
- Sharon Sedaris — Mother
- Gretchen Sedaris — Sister