Nancy discovers that her new beau (Martin Donovan) is a DEA agent; Celia decides to run for city council---against Doug; Andy applies to rabbinical school and faces a tough admissions officer (Meital Dohan).
After breaking up with the DEA agent (Martin Donovan), Nancy attends a “small-business expo” devoted to growing pot; Conrad canvasses partners in an attempt to come up with seed money for his own marijuana enterprise. Also, Megan (Shoshannah Stern) gets accepted into Princeton, and Silas feels like he may be getting left behind.
Peter (Martin Donovan) deals with the fact that Nancy's a drug dealer; Celia sends Isabelle to a weight-loss boot camp in preparation for her summer stay at fat camp; Shane crosses the threshold of puberty.
There's progress on the grow house until a menacing neighbor makes an unexpected and surprising threat; Uncle Andy has a solution when Shane gets ridiculed in school because of his limited sexual experience; Heylia is courted by a member of the Nation of Islam; Dean gets downsized from the firm; Isabelle is offered a job modeling a clothing line for larger children.
Nancy gets a special favor from a special friend in her neighborhood war with her main competition, the Armenian dealers; Megan goes by herself to tell her parents she's pregnant; Isabelle auditions as a model for a large-kids' clothing line; Celia debates Doug; at school, Shane gets caught bragging about his visit to a massage parlor.
Conrad confronts Nancy about her special arrangement with Peter (Martin Donovan) and she secretly arranges a three-way meeting; new model and sole family breadwinner Isabelle hires Doug to manage her finances; Vaneeta dishes out some sizzling hostility over dinner with Heylia's new Muslim boyfriend; Shane has a crush on a girl in his debating club; Andy discovers Yael's fetish.
The new weed is ready and Nancy's first sale is to a record engineer who wows his boss, Snoop Dogg (as himself), with the potent pot; Celia brings her anti-drug program to Agrestic Elementary School; Heylia discovers that Nancy and Conrad have been dealing behind her back.
Peter (Martin Donovan) pressures Nancy to get out of the business; Shane realizes what his mother does for a living; Doug and Celia discover that politics really does make for strange bedfellows; Silas, Shane and Andy commemorate the late Judah's birthday with a special celebration.
With the DEA coming down hard on Heylia, she pressures Nancy to right some wrongs; Nancy and Conrad try to put Peter off the trail; Celia and Doug's affair heats up; Andy's loopy ex (Zooey Deschanel) arrives unannounced from Alaska.
Peter makes some serious demands involving his and Nancy's marriage and the pot profits; Heylia heads for prison, but not before making a deal with the Armenian pusher (Arthur Darbinyan); Celia tells Dean she's leaving him for Doug; Andy's ex refuses to leave.
Nancy and Conrad hope to finalize their monumental pot deal; Shane delivers a memorable graduation speech; Celia thinks she knows who's been vandalizing her drug-free zones; and Conrad seeks Heylia's help with the DEA-agent Peter situation.