Follow the madcap adventures of the original game of cat and mouse as Tom, an ordinary gray and white house cat, of no great intelligence is driven by three goals: to eat, to sleep and to catch the mouse, Jerry ... and eat him.
Hunting in the woods, Tom wounds a duckling, little Quacker, who is doctored by Jerry.
Tom and Jerry are touring through Naples and they encounter an Italian mouse.
A depressed baby duck thinks he is ugly after reading "The Ugly Duckling" and wants Tom to eat him but Jerry keeps preventing that.
Jerry hides in Spike and Tyke's basket to escape from Tom but a food fight erupts between all of them including an army of ants as they all vie for control of the basket.
Tom and Jerry are forced to take care of a baby because the babysitter is more interested in talking on the phone.
Jerry rescues some puppies and Tom doesn't want the one that followed him home around.
Tom is the lesson when Spike is teaching his son Tyke the facts about chasing cats.
Tom chasing Jerry around always destroys Spike's efforts to build his own dog house.
Jerry is forced to take care of a baby woodpecker and try to avoid Tom while doing it.
Jerry helps out Spike by removing a tack from his foot and the bulldog helps him out by beating up Tom.
Tom accidentally grabs Tyke, Spike the bulldog's son, when he is trying to get to Jerry.
Tom and his alley cat pals are laughing as they watch home movies involving Tom outwitting Spike but Jerry decides to let the bulldog know about it.
Tom gets tired of chasing Jerry so he takes a seat and finds Jerry's Diary which he checks out.