Maria goes to court to decide who gets custody of her two children when she dies; a mother fighting metastatic cancer goes on a road trip with her daughter; a dying man makes his final wish and it leaves his wife of 49 years speechless.
Little struggles in her new role as primary caretaker of her mom and her two younger siblings. Meanwhile, a man in the advanced stages of ALS seeks redemption for past transgressions and a reunion with his mother and two sons he's never known.
Maria gets excited about a new clinical trial, but her children become alarmed when radiation treatments begin affecting her physical and mental capacities. Meanwhile, a psychotherapist with pancreatic cancer prepares to say goodbye to her husband, sons and grandchildren.