Baltimore (8-6) at Pittsburgh (9-5). In this key AFC North clash, the Steelers can clinch the division with a win, but could fall out of the playoffs with a loss. The Ravens, who won 21-14 in Week 9, can claim the division with wins today and next week.
Cincinnati (5-8-1) at Houston (8-6). With last week's loss to Pittsburgh, the Bengals will miss the postseason for the first time since 2010. Houston can earn a playoff spot with wins today and next week against the Titans, who share the AFC South lead.
New York Giants (10-4) at Philadelphia (5-9). The Giants can clinch a playoff spot with a win over the Eagles, who fell 28-23 when these teams met in early November. Eli Manning tossed 4 TD passes--two to Odell Beckham Jr.--in the Week 9 victory.
Miami (8-5) at New York Jets (4-9). QB Matt Moore gets his first start in five years for the Dolphins, whose 7-1 run includes a 27-23 win over New York, clinched by Kenyan Drake's 96-yard kick-return TD. Bilal Powell faces Miami's 30th-ranked run defense after recording his second-career 100-yard rushing game in a comeback win in San Francisco.
Los Angeles (4-9) at Seattle (8-4-1). Following blowout losses on Sunday, L.A. begins the post-Jeff Fisher era (under interim coach John Fassel) while the Seahawks (6-0 at home) look to sew up the NFC West title. The Rams stymied Seattle 9-3 in Week 2 in their return to L.A., improving to 4-1 in the last five meetings.
Oakland (10-2) at Kansas City (9-3). QB Derek Carr and the resilient Raiders take a 5-0 road mark into this pivotal AFC West matchup, facing DBs Eric Berry and Marcus Peters of K.C., which allowed just 285 yards in dominating a Week 6 meeting 26-10. Alex Smith completed 19 of 22 pass attempts and Spencer Ware ran for 131 yards and a score in the Chiefs' fourth straight win in the rivalry.
Dallas (10-1) at Minnesota (6-5). The Cowboys ride a team-record 10-game winning streak into U.S. Bank Stadium, with rookies Dak Prescott and Ezekiel Elliott facing a stern test in Mike Zimmer's defense (307 ypg). Dallas last won on Vikings turf in 1995.
New Orleans (4-5) at Carolina (3-6) in a clash of NFC South rivals both coming off dramatic home losses. The Saints edged Carolina 41-38 in Week 6 as Drew Brees threw for a season-high 465 yards and 4 TDs. Will Lutz hit a last-minute 52-yard field goal as well, ending the Panthers' three-game run in the series.
Cleveland (0-9) at Baltimore (4-4). John Harbaugh's AFC North co-leaders are riding a 15-2 run against Cleveland after erasing the Browns' largest lead of the season (20 points) to win 25-20 in Week 2. Mike Wallace had 2 TD catches in the victory and scored on a Ravens-record 95-yard catch-and-run in last week's big win over Pittsburgh.
Atlanta (5-3) at Tampa Bay (3-4). The Bucs go for a season sweep of division-leading Atlanta while bidding for their first home win since beating the Falcons last December. Tampa Bay won the teams' Week 1 duel 31-24 behind Jameis Winston's 4 TD passes and Kwon Alexander's 17 tackles. Bucs head coach Dirk Koetter and assistant Mike Smith worked together with Atlanta from 2012-14.
Jacksonville (2-4) at Tennessee (3-4). The Jaguars look to improve on an AFC-worst 76.7 rushing yards/game, while the Titans own one of the league's top rushing attacks (143.4), led by DeMarco Murray. Last year's series split saw Tennessee win 42-39 here to break an 11-game home losing streak.
New York Giants (3-3) vs. Los Angeles (3-3) at Twickenham Stadium in London. British fans at this rugby venue may warm to New York WR Odell Beckham and L.A.'s Kenny Britt, who both come off season-best games. The Giants are on a 6-0 run against the Rams, winning the last five by double-digits. New York's minus-10 turnover ratio ranks at the bottom of the NFC.
Chicago (1-5) at Green Bay (3-2). Rookie RB Jordan Howard and the Bears face a hurting Green Bay defense that allowed more run yards in last week's loss to Dallas (191) than in its first four games combined. The Packers are on a 10-2 run in this rivalry, losing 17-13 last season at Lambeau Field, where they are capping a stretch of four straight games (2-1 thus far).