San Diego (8-6) at San Francisco (7-7). Mike McCoy's Chargers are alive for a wildcard while the 49ers' three-game slide has knocked them out of the contention. Corey Luiget leads the chase of QB Colin Kaepernick, who's been sacked an NFL-high 49 times.
Philadelphia (9-5) at Washington (3-11). Chip Kelly's Eagles try to shake off their first back-to-back losses since last October, looking to sweep Washington after taking a 37-34 slugfest on Sept. 21. Ex-Philly WR DeSean Jackson had 117 yards and a TD.
Arizona (10-3) at St. Louis (6-7). QB Drew Stanton directs the NFC West-leading Cardinals against a St. Louis defense coming off back-to-back shutouts. Arizona rallied past the Rams 31-14 on Nov. 9, getting a pair of late fourth-quarter TDs on defense.
Dallas (8-4) at Chicago (5-7). NFL rushing leader DeMarco Murray and the Cowboys take a 5-0 road record to Soldier Field, where Marc Trestman's Bears dismantled them 45-28 last December, scoring on their first eight possessions in frigid conditions.
Kansas City (7-3) at Oakland (0-10). Andy Reid's Chiefs moved into a share of the AFC West lead with their win over Seattle on Sunday, while Oakland has now gone over a year without a win. Jamaal Charles had 5 TDs in K.C.'s 56-31 win here last season.
Buffalo (5-4) at Miami (5-4). Doug Marrone's Bills got their third-straight victory over Miami on Sept. 14, riding five field goals from ex-Dolphin Dan Carpenter to a 29-10 win. Buffalo sacked Ryan Tannehill four times and now lead the league with 34.
New Orleans (3-4) at Carolina (3-4-1). The Saints try to shake a 1-8 road slide that includes last season's 17-13 loss here on a late TD pass by Cam Newton. Fellow Heisman winner Mark Ingram of New Orleans ran for a career-best 172 yards four nights ago.
San Diego (5-2) at Denver (5-1). Top-rated AFC passers Peyton Manning and Philip Rivers eye tight ends Julius Thomas (9 TDs) and Antonio Gates (7) in a West division showdown. Denver held off the Chargers 24-17 in a Divisional playoff last January.
New York Jets (1-5) at New England (4-2). Tom Brady and the Patriots' 11-game home winning streak includes a 13-10 Thursday-night win over the Jets last season. New England tops the NFL in turnover ratio (plus-9) while Rex Ryan's Jets are last (minus-9).
Minnesota (2-2) at Green Bay (2-2). The Packers are on a 7-1-1 run in this NFC North rivalry, settling for a 26-26 tie at home last season with QB Aaron Rodgers out injured. Brett Favre led the Vikings to their last Lambeau Field win in 2009.
New York Giants (1-2) at Washington (1-2). These NFC East rivals put up season-high yardage totals on Sunday, with Kirk Cousins throwing for 427 of Washington's 511 total yards in a loss to Philly. New York swept last season's series 24-7 and 20-6.
Tampa Bay (0-2) at Atlanta (1-1). Lovie Smith's Bucs have two losses to backup QBs, running Tampa's September losing skid to nine in a row. Injuries have plagued new linemen Logan Mankins and Jake Matthews in front of QBs Josh McCown and Matt Ryan.