When Ralphie gets sick and can't attend school, Ms. Frizzle brings the class to him, where they get the inside story on why Ralphie's ill by traveling through his bloodstream. Voices...Ms. Frizzle: Lily Tomlin. The Producer: Malcolm-Jamal Warner. Ralphie's Mom: Tyne Daly.
Ms. Frizzle (voice of Lily Tomlin) takes the group on an outing to the planetarium. Finding it closed, they blast off into outer space. But trouble threatens their tour when the teacher gets lost in space.
The Friz and the class blast off for outer space when budding astronomer Dorothy Ann claims to have seen an asteroid heading for Earth. Features the voice talent of Swoosie Kurtz (as Dorothy Ann's mother) and Lily Tomlin (Ms. Frizzle).
The Friz and class find themselves going around and around as part of the water cycle, and Arnold is concerned that they'll be stuck forever in a never-ending rotation of evaporation, condensation and precipitation. Voice of Ms. Frizzle: Lily Tomlin.
The class sets sail on a mission to discover its own island and gets submerged in an effort to retrieve Dorothy Ann's lost books. Voices...Ms. Frizzle: Lily Tomlin. Dorothy Ann: Tara Meyer. Carlos: Daniel DeSanto.
An outing to a body shop provides the students with the items they need to build a robot, but they must learn how bodies work to operate their creation. Voices...R.U. Humerus: Tony Randall. Ms. Frizzle: Lily Tomlin. Ralphie: Stuart Stone.
After seeing dinosaur bones at an archaeological dig, the class journeys back in time to learn more about the reptiles. Voices...Dr. Carmina Skeledon: Rita Moreno. Ms. Frizzle: Lily Tomlin. Phoebe: Maia Filar.
When Ms. Frizzle arranges a meeting to show parents what the class is learning about bats, Ralphie believes that the grown-ups' safety may be at stake. Voices include Tyne Daly, Eartha Kitt, Edward James Olmos, Elliott Gould and Dana Elcar.
A Halloween outing to a museum becomes an exhibit of fear when students become separated and meet a stranger who's full of stories. Among them is a tale about a kid's search for "the perfect sound" at a haunted house. Shown in live-action and animated sequences.
When Arnold and his cousin Janet disappear in a haunted theater, Ms. Frizzle tries to shed some light on the situation. But things get even eerier when Arnold's ghostly image appears, hovering over the stage.