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Hugh is shocked when he finds out Penny accepts a job in the city and the hospital is thrown into chaos. Charlie develops an unhealthy obsession over Hugh's relationship with Penny.
Hugh faces a dilemma when his best friend Joey makes a dying wish. The Knight family rallies to support Ajax and Meryl as they each confront a major crisis.
When Hugh gets permission to perform minor surgeries, he’s desperate to find a patient who needs to go under the knife. At a family dinner, Meryl announces that she’s going to run for Mayor, but no one is too thrilled about the idea. Hugh decides he wants to tell Ajax that he’s his father, but his family doesn’t think it’s the best idea.
Hugh gets a running start to his day, when a worker named Jazz goes on a meth-fuelled psychotic break outside the hospital, and ends up chopping off part of his penis. And that’s not the only thing thrown his way - Aoife tells him she loves him... and gives him 24 hours to say it back.