Pablo's plan to make his mad crush Cherie the school's Valentine's Day Queen backfires when his sister wins by one vote. Cherie vows revenge and her evil daddy, Quba, guarantees to crush Zoe with the help of the legendary Achilles.
Its picture day and Zoe has a pimple. In fact, almost everyone in town does due to Mascot's newest food creation; deep fried, chocolate-covered ice cream sundae pizza and the mayor has put the supply of pimple cream under military guard.
After Pablo and Leo eat themselves sick with junk food, Zoe insists they eat healthy and begins making everyone horrible concoctions. Meanwhile Quba plans to use The Colossus to block out the sun and then sell glow-in-the-dark paintings.
Its party on as Pablo disguises himself as his sister Zoe to crash Cherie's all-girl party. But when St. George's Dragon kidnaps him, it's up to Zoe to disguise herself as a knight to rescue her hapless brother from the flying beast.
When Zoe's award-winning glass sculpture is chosen for the town square, a jealous Quba sets out to shatter it with the high-pitched vocal stylings of one of the greatest singers in history, India's Bani Thani.
Choochie has fleas and Cherie is itchy and miserable. Pablo steps up to try and get rid of them. The S.V.B.V. are so crazy with Choochie's itchy fleas that Quba sends Mascot to Spray Alive the Pied Piper so he can lead the fleas out of the pizza parlor.
Pablo and Zoe get in a competition to see who can post the most embarrassing video of the other on their blog, but their battle is interrupted when the Two Tenors Spray Alive Alexander Graham Bell and use him to take over the internet.
Zoe volunteers to be a tutor to impress the new and very smart kid in school, Brian. But Zoe is horrified when she gets stuck tutoring Cherie. And after Pablo fails a chemistry test, he's forced to be tutored by Brian.
Quba uses Spray Alive on Romeo and Juliet, so Juliet can tell him Shakespeare's long lost recipe for pizza sauce the legendary sauce is so delicious Quba plans to paint with it so everyone will love his paintings. But Cherie steals away dreamy Romeo.
Uncle Leo's new pet frog has a monotonous croak that makes him more popular than the SVBV's own villainous Tenors. When the jealous singers take the annoying frog from a relieved Pablo and Zoe, the guilty siblings realize they have to get it back.
Uncle Leo and Zoe are dancing finalists on a reality TV show. When Leo gets injured, Pablo must fill in and dance with his sister against some deadly competition: Mascot and one of the most famous dancers in history.
Pablo's playing his favorite video game so long he starts to see evil invading aliens everywhere he looks. Meanwhile, Quba uses Spray Alive on a giant wombat statue from Australia to smash an art gallery that won't hang his paintings.
When Zoe accidentally saves Dr. Meanie's life, the two become best friends forever. But Quba wants his favorite evil scientist back and he vows to make her jealous by crushing the DaVincis with the help of his new scientist, Sir Isaac Newton.
Pablo and Zoe are throwing the party of the semester, but after Mascot isn't invited, he vows revenge. Mascot heads to the Louvre and uses Spray Alive on Bacchus the god of parties to throw the party of the century.
Pablo's the judge at a beauty pageant, but will he choose his sister or his true love, Cherie, the daughter of the leader of the SVBV who doesn't even know his name? He might not choose either if Venus De Milo has anything to say about it.
The Society of Very Bad Villains battles the DaVincis in outer space. The DaVincis need to deliver a supply of potato chips to the orbiting space station while Quba wants to carve his "handsome" face onto the surface of the moon.
Pablo wins the lead in Hamlet, but the role of Ophelia doesn't go to his mad crush Cherie, it goes to his sister Zoe. Cherie vows revenge and has her father bring in the real Hamlet to make things right...by telling Hamlet that Zoe killed his father.
It's a Presidential Smackdown when the DaVincis travel to Washington, DC, and their trip turns into the "battle of several centuries." Eager to crush his mortal enemies, Quba animates the statue of Abraham Lincoln to do his evil bidding.
A fight over an ancient TV remote clicks Pablo and Zoe into the middle of a televised wrestling match. The Society of Very Bad Villains tries to keep them from ever finding their way home by forcing them to wrestle, The Bronzes of Riace.
Pablo is so depressed about Cherie's ongoing rejections, Uncle Leo cancels the family vacation to Milan much to Zoe's dismay. Meanwhile, Quba's in love with an art critic who just happens to think he's the worst artist in the world.
Another birthday for Zoe and another year where Pablo forgets. As Zoe wishes she had a new brother, Quba paints a portrait of Pablo, uses his Spray Alive and sends "fake Pablo" to destroy the DaVincis. But Fake Pablo and Zoe hit if off.