Season 2 opens with Cathy seeking a second opinion about her cancer, which doesn't sit well with Dr. Todd. Meanwhile, Sean discovers that his sister is battling cancer while he's dealing with the growing pains of living with a pregnant Rebecca; and Adam is less-than-happy about seeing a therapist.
Cathy tries dabbling in the supernatural after she's unsuccessful at scoring a spot in a clinical trial for a new cancer treatment overseen by a renowned oncologist (Alan Alda). Meanwhile, Sean takes on a take-charge attitude around the house, and Adam uses his mother's medical situation to his advantage at school.
Problems in the bedroom plague Cathy and Paul, but some insight from their new housemate, Andrea, goes a long way in getting things situated. Meanwhile, newly medicated Sean ruffles Rebecca's feathers; and Adam isn't getting what he wants from his relationship with Mia, so he hooks up with another girl.
Cathy makes a new acquaintance in a fellow cancer patient (Hugh Dancy) on the first day of the clinical trial. Meanwhile, troubled Adam gets in a fight at school, and Sean suspects his house may be haunted.
Paul's layoff has Cathy concerned about their financial situation and she considers pawning her jewelry, but a surprise encounter with Lee causes her to reconsider. Meanwhile, Adam lands in hot water after getting caught in a compromising position; and Sean field-tests his eco-friendly homemade sling in front of the moms at a neighborhood park.
Paul plays matchmaker for Andrea and the Ukrainian coworker he is mentoring; an indiscreet Adam is responsible for jeopardizing Cathy's new job as a swim coach; and Sean contemplates taking the next step with Rebecca and seeks advice on how to go about it.
Lee takes Cathy to a Tibetan doctor to help lower her blood pressure for the clinical trial; a jealous Paul goes to a bar with Lee and Cathy; a grounded and bored Adam interferes with Andrea's date with Myk.
Thanksgiving dinner at Cathy's house is thrown into turmoil after she reveals a long-hidden secret. Meanwhile, Paul contemplates an alternative source of income when faced with increasing insurance costs.
Rebecca has an unusual way of dealing with her miscarriage and the result leaves Cathy reconnecting with friends from the past. Elsewhere, Andrea and Myk's relationship goes to a new level; Adam gets a surprise when he meets a girl he's been chatting up on an online cancer group.
In the second-season finale, Lee's passing has a profound effect on Cathy and she decides on a special way to ring in the New Year. Meanwhile, continued financial woes lead Paul to try a different tack with the insurance company; and Adam and Dr. Todd make a surprising connection.