A disgraced Goddard runs away from home after being disqualified from the Retroville Pet Show for not being a “real” dog; Mr. Estevez, with help from Jimmy, attempts to convince Sheen that he's a real-life superhero named El Magnifico.
Jimmy, Carl and Sheen are captured and enslaved by a mad scientist while investigating the mystery of the Bahamas Quadrangle. Later, Carl turns to Jimmy for a quick way to increase his IQ and his chances with a cute exchange student from Sweden.
Jimmy forms an unlikely alliance with Cindy to figure out why the people of Retroville are acting stranger than usual; Jimmy performs a magic trick that goes horribly wrong when he and his friends are transported to an alternate universe.
Timmy Turner from “The Fairly OddParents” returns to Retroville and ends up getting into a rivalry with Jimmy over which of the boys Cindy will escort to an upcoming Friday the 13th dance. Meanwhile, Professor Calamitous (voice of Tim Curry) hatches a plan to get Wanda and Cosmo to become his evil accomplices.
Cdr. Baker (Michael Clarke Duncan) recruits Jimmy to keep tabs on bad girl Beautiful Gorgeous (Wendie Malick) after she's sprung from prison. To Jimmy's utter shock, he finds Beautiful with his hero, Jet Fusion (Christian Slater), who has had a change of heart regarding the super-villainess.
Jimmy is kidnapped and held prisoner in the farthest reaches of space by a group of his enemies who have teamed up under the leadership of King Goobat (voice of S. Scott Bullock). Not willing to stand by and do nothing when their friend is in trouble, Sheen, Libby, Carl and Cindy use one of Jimmy's experiments to give themselves super powers. Other voices include...Professor Finbar Calamitous: Tim Curry. Beautiful Gorgeous: Wendie Malick. Tee: Kevin Michael Richardson.