After years of searching, Rex's brother, Titanium Dax, becomes the second Subtopian ever to breach Earth's surface. He and his rock monster slave, Liplor, are thrilled to find Rex alive, but their reunion is soured when Dax threatens to reveal a secret about Rex's origins.
A giant alien plots to destroy Earth after learning that Black Saturn transformed his pal into a baby monkey, prompting the League to travel into space in an attempt to thwart his planet-destroying machine.
Titanium Rex tries to persuade an old friend into joining the League in hopes of restoring their tarnished reputation. Meanwhile, Black Saturn introduces Jewbot to fraternity life; and the rest of the League experience college for themselves.
In the Season 2 premiere, the League of Freedom is still reeling following the destruction of the SuperMansion, as all the villains roam freely throughout Storm City. Meanwhile, American Ranger helps Cooch cope with Brad's death; and Titanium Rex and Jewbot team up to prevent a cult from leaking sensitive intel.