Samantha Who?

An accident victim awakens from an eight-day coma with amnesia and must start over. As she does, she learns she wasn't a nice person.

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Season 2, Episode 10 My Best Friend's Boyfriend

First Aired: March 26, 2009

Sam and Todd double-date with Andrea and pro basketball player Tony Dane. But Todd discovers there's something about Tony that could affect Andrea's interest, and Sam can't help meddling. Dena asks Regina for help after developing an online relationship with a lonely soldier that could make Chase jealous.

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Guest Cast

Tony Dane
Stephen Rannazzisi Seth

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  • Premiered: October 15, 2007
  • Rating: TV-14
  • Premise: An accident victim awakens from an eight-day coma with amnesia and must start over. As she does, she learns she wasn't a nice person. (more)
Cast
Christina Applegate Christina Applegate Samantha `Sam' Newly
Jennifer Esposito Jennifer Esposito Andrea
Kevin Dunn Kevin Dunn Howard
Melissa McCarthy Melissa McCarthy Dena
Tim Russ Tim Russ Frank
Jean Smart Jean Smart Regina

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