While helping Fluttershy gather supplies, Zecora comes down with a terrible disease called swamp fever. Even though a cure has not been discovered, Fluttershy makes it her mission to heal Zecora no matter what it takes.
Spike accidentally invites Ember and Thorax to Ponyville on the same day, and he's sure the two new leaders are not going to get along, so he does all he can to keep them apart and cover the fact that the other is there.
Pinkie Pie visits Prince Rutherford and the Yaks, but an avalanche falls on the entire rustic village of Yakyakistan. Pinkie Pie suggests that she go get the other ponies to help, but the proud prince and Yaks refuse.
Starlight Glimmer is sent to solve a friendship problem between Princess Celestia and Princess Luna, but when it's clear that the problem is that the royal sisters don't appreciate one another, Starlight impulsively switches their cutie marks.
Fluttershy's determined to make her career dreams come true with the help of some special ponies. However, Fluttershy's vision is not being executed properly, so she must find a way to stand up and fight for her ideas.