In the series finale, a bed-bug infestation in their building sends the gang to secretly crash at the vacationing Lou's pad, where they unknowingly snack on some special Oscar "treats," and to complicate matters, he cuts short his getaway and returns unexpectedly.
John may find himself home alone over Christmas when he lets his resentment of actor Macaulay Culkin impact the holiday. Meanwhile, Lou learns that his network-host rival is planning a yuletide special to compete with his; and Andre gets mistaken for a puppet.
Motif is put out and turns to his three girlfriends for support when John and Jane refuse to add him to the lease on the apartment. Meanwhile. the stooge Lou plants in his audience demands to be put under contract.
Jane's romantic relationship with a marine triggers guilt pangs in John and Motif for never having served in the military, so they sign up for a USO comedy tour. Meanwhile, Lou recalls how war and improv make for a hellish combination.
John, a struggling stand-up comedian, takes a job writing for a difficult game-show host in the premiere of this sitcom based on the life and comedy of entertainer John Mulaney. Meanwhile, John's roommate Jane tries to prove to an ex that she isn't crazy; and his other roommate Motif attempts to write a joke with a great punch line.