Comedian Louis C.K. plays himself, sort of, in a sitcom about a newly single stand-up comic raising two daughters in New York and reflecting on his life in his act. In the opener, Louie accompanies them on a school field trip and also goes on a date. Neither goes well.
Louie goes to a doctor (Ricky Gervais) who's a high-school friend with an odd sense of humor. Then, after performing at the Comedy Cellar, he dines with another old pal (Nick Di Paolo), a fellow comedian with wildly differing political opinions.
Louie sets up a play date for his daughters with the son of a dour woman (Pamela Adlon) he meets at a PTA meeting. He also receives an unusual compliment from a young woman who caught his act at the Comedy Cellar.