Premise

The one-time comedy writer hosts a popular late-night talk show. O'Brien succeeded David Letterman in NBC's post-`Tonight' slot in September 1993 after a writing and producing career that included `The Simpsons' and `Saturday Night Live.'

Cast

Guest Stars

Al Roker
13 Episodes (2000-2008)
Ice-T
12 Episodes (2000-2008)
Tina Fey
12 Episodes (2001-2008)
Bob Saget
8 Episodes (2005-2009)
Chris Rock
8 Episodes (2000-2007)
Paul Rudd
8 Episodes (2002-2009)
Heidi Klum
8 Episodes (2000-2008)
Ray Liotta
7 Episodes (2001-2008)
Snoop Dogg
7 Episodes (2001-2008)
Zach Braff
7 Episodes (2001-2007)
LL Cool J
6 Episodes (1999-2007)
Ted Danson
6 Episodes (2001-2007)
Tyra Banks
6 Episodes (2000-2007)
Louis C.K.
6 Episodes (2003-2008)
Joy Behar
6 Episodes (2000-2007)
Alan Alda
5 Episodes (2005-2008)
Bernie Mac
5 Episodes (2001-2007)
Jack Black
5 Episodes (2000-2006)
Jamie Foxx
5 Episodes (2001-2007)
Jeri Ryan
5 Episodes (2000-2003)
Jon Lovitz
5 Episodes (2000-2006)
Neil Young
5 Episodes (2004-2006)
Omar Epps
5 Episodes (2000-2006)
Matt Lauer
5 Episodes (2001-2009)
Jewel
5 Episodes (2002-2008)
John Mayer
5 Episodes (2002-2008)
Joe Buck
5 Episodes (2003-2008)
Todd Barry
5 Episodes (2000-2008)
Andy Dick
4 Episodes (2000-2004)
DJ Qualls
4 Episodes (2002-2007)
Dane Cook
4 Episodes (2005-2008)
Ice Cube
4 Episodes (2002-2007)
Jason Lee
4 Episodes (2002-2008)
Jim Breuer
4 Episodes (2000-2002)
Jim Carrey
4 Episodes (2003-2008)
Lucy Liu
4 Episodes (2003-2006)
Luke Perry
4 Episodes (2001-2006)
Mike Myers
4 Episodes (2001-2008)
Steve Zahn
4 Episodes (2002-2007)
Tom Green
4 Episodes (2001-2004)
Tom Hanks
4 Episodes (2002-2006)
Tony Danza
4 Episodes (2001-2004)
Vin Diesel
4 Episodes (2003-2008)
B.J. Novak
4 Episodes (2004-2008)
Ann Curry
4 Episodes (2000-2008)
Bill Hader
4 Episodes (2006-2008)
Larry King
4 Episodes (2002-2007)
Ali G
4 Episodes (2003-2007)
Masi Oka
4 Episodes (2006-2008)
Tim Gunn
4 Episodes (2006-2008)
Bill Maher
3 Episodes (2003-2008)
Clive Owen
3 Episodes (2005-2009)
Edie Falco
3 Episodes (2001-2006)
Eva Mendes
3 Episodes (2007-2008)
Jude Law
3 Episodes (2004-2006)
Liv Tyler
3 Episodes (2001-2007)
Matt Damon
3 Episodes (2000-2005)
Mike Epps
3 Episodes (2002-2008)
Rob Lowe
3 Episodes (2000-2006)
Diddy
3 Episodes (2002-2007)
Simon Pegg
3 Episodes (2007-2008)
Tara Reid
3 Episodes (2001-2002)
Téa Leoni
3 Episodes (2004-2007)
Molly Sims
3 Episodes (2004-2006)
Seth Rogen
3 Episodes (2007-2008)
Beck
3 Episodes (2000-2003)
Moby
3 Episodes (2004-2008)
Ted Koppel
3 Episodes (2007-2008)
Will Forte
3 Episodes (2005-2008)
Ed Helms
3 Episodes (2006-2008)
Aimee Mann
3 Episodes (2000-2006)
John Cena
3 Episodes (2006-2008)
Ed Burns
3 Episodes (2001-2003)
Jonah Hill
3 Episodes (2006-2008)
Tea Leoni
3 Episodes (2004-2007)
Adam Brody
2 Episodes (2005-2007)
Amy Adams
2 Episodes (2006-2008)
Dana Gould
2 Episodes (2007-2007)
Diane Lane
2 Episodes (2003-2008)
Eric Bana
2 Episodes (2003-2004)
Eve
2 Episodes (2002-2004)
Helen Hunt
2 Episodes (2001-2001)
Ja Rule
2 Episodes (2003-2004)
James Caan
2 Episodes (2000-2003)
Jay Mohr
2 Episodes (2000-2004)
Kevin Hart
2 Episodes (2004-2005)
Matt Stone
2 Episodes (2001-2004)
Mila Kunis
2 Episodes (2004-2005)
Mos Def
2 Episodes (2001-2007)
Peter Falk
2 Episodes (2003-2005)
Ray Romano
2 Episodes (2001-2006)
Ron Howard
2 Episodes (2003-2009)
Roseanne
2 Episodes (2002-2003)
Scott Wolf
2 Episodes (2003-2006)
Sean Hayes
2 Episodes (2008-2008)
Snoop Dogg
2 Episodes (2001-2008)
Val Kilmer
2 Episodes (2003-2005)
Kelly Ripa
2 Episodes (2002-2003)
Mr. T
2 Episodes (2001-2006)
Xzibit
2 Episodes (2006-2007)
Common
2 Episodes (2005-2008)
Al Gore
2 Episodes (2002-2007)
Andy Blitz
2 Episodes (2002-2003)
Ed Burns
2 Episodes (2001-2003)
Jamie King
2 Episodes (2003-2005)
Pink
2 Episodes (2006-2008)