A breakout hit chronicling life with a Pennsylvania family with two sets of multiples (twins and sextuplets). The first four seasons offer a mostly endearing look at life in a large family, but the series took a more serious turn in Season 5 when Jon and Kate announced they were separating. The subsequent discord led to the end of the series at the conclusion of that season, in 2009.
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Here's how everything changed in "Chapter 6"