As a police investigation gets underway after Simon's accidental shooting, the "K4" deal with a new set of obstacles. Meanwhile, a distraught Annalise finds herself in an unimaginable situation as Laurel and her baby struggle to cling to life.
Annalise is confronted with disturbing news involving one of Isaac's patients that puts her sobriety at risk. Meanwhile, the investigation into Wes' murder comes to a head, and the details involving Laurel's baby are revealed.
Annalise's resolve is tested as she works on her class-action lawsuit, and a surprising ally comes to her aid. Meanwhile, Laurel and Michaela hit a roadblock after someone discovers their plans to take down Laurel's father.
Annalise forges ahead with her class-action lawsuit and receives help from a former colleague. Meanwhile, Laurel continues to investigate her father's company; Asher confronts Michaela about her odd behavior; and details about Isaac's past are revealed.
Bonnie has suspicions about Annalise's big case, and they drive her to great lengths to get answers, while flashbacks reveal the genesis of the two women's long and complicated history. Also, a flash-forward shows the whereabouts of one of the Keating 4.
Annalise feels like she's found her purpose again as she focuses on developing a big case, but Bonnie grows suspicious. Meanwhile, Connor gets a surprise visit from his dad; and Laurel turns to an old friend to relieve some stress.
Annalise takes on a case for the greater good and realizes the stakes are higher than she thought. Meanwhile, Laurel asks Michaela to help get info regarding Wes' death; and Connor makes a major life decision, but it's not supported by the group.
Annalise reconnects with a client from her past, but her personal life remains a struggle. Meanwhile, the Keating 4 find it difficult to move beyond their tarnished reputations; and in a flash-forward, details concerning a tragic crime begin to unfold.
In the fourth-season opener, Annalise returns to her family home to pick up the pieces of her life. Meanwhile, Laurel becomes obsessed with finding out what happened to Wes the night he died; and in a flash-forward, a terrifying crime is committed.