Ellen tells Duncan that she will not kill the president but that she will help him get what he needs in return for something she wants. Meanwhile, Nina learns about Duncan's plan and flees the hospital.
Brian goes to the police to expose Duncan, but Burton shows up and presents him with evidence that Ellen and Duncan are getting close. Meanwhile, Duncan's trip to New York City threatens to derail his plan to kill the president.
Duncan locks the Sanders family in a room for the day while he and his unit go to New York to eliminate the two-person sniper team targeting the president. Meanwhile, Nina's mother tells Burton that she wants to expose the president.
Duncan is ordered by someone closely connected to the plot to get rid of an insider when investigators get closer to discovering the conspiracy to kill the president. Meanwhile, Duncan takes the next step in his master plan, and gives Ellen the poison she is to use to kill the commander in chief.
Ellen must decide whether to save Duncan's life and confront his wife. Meanwhile, Creasy meets with Vanessa and Col. Blair after the president informs them that he wants to expose a government surveillance program that allowed spying on U.S. citizens.
Ellen's sister visits unexpectedly and Duncan forces Ellen to get rid of her without making it look suspicious. Later, Ellen is called in for questioning by the secret service and must play it cool because Duncan is there to help with the questioning.
Duncan threatens Ellen that if she doesn't convince the president to keep her on as his surgeon that there will be severe consequences. Meanwhile, Ellen meets Duncan's daughter and gains insight into his life.
Duncan promises to kill a member of Ellen's family when she refuses to assassinate the president during surgery. Duncan also informs the family to go about their normal lives for the next two weeks until the commander in chief's operation.
A deadly cat-and-mouse game between a surgeon and a rogue FBI agent begins. In the opener, Dr. Ellen Sanders is selected to operate on the U.S. president but armed intruders take her family hostage and demand that she kill him during surgery or they will murder her family.