The Season 2 opener reveals the fates of Nathan, Peter and Matt after the face-off with Sylar, as a new threat presents itself to those on the list. In other events, Hiro meets his idol in feudal Japan; and the Bennets strive for normalcy in California. Nick D'Agosto, Lyndsy Fonseca, Cristine Rose, Barry Shabaka Henley, George Takei, Eriko Tamura and Adair Tishler.
Claire's efforts to keep her abilities hidden are compromised by someone with a secret of his own; Suresh is ordered to look for The Haitian; Niki and Micah leave Las Vegas; Matt makes a surprising request for help as he investigates the attacks on people with abilities.
Suresh fears for a friend after unearthing a painting by Isaac that foretells death. Ando returns to Japan and makes a happy discovery; while in the past, Hiro is surprised by his childhood hero, Kensei. And two familiar faces return unexpectedly.
Matt asks Molly to find the man haunting her dreams, but the outcome is not pleasant; H.R.G. suspects Claire has a new boyfriend; Angela has shocking news; and Micah's cousin Monica (Dana Davis) finds herself with some unanticipated new abilities.
A mysterious woman (Kristen Bell) searches for Peter; Matt and a surprise ally go to Philadelphia to hunt down Molly's attacker; Monica deals with her new abilities and her role as a local hero; Suresh meets his new partner; and Ando traces Hiro through history.
West encourages Claire to teach the snobby head cheerleader a lesson; Alejandro is wary of Sylar's intentions toward Maya; H.R.G. hunts for the last of Isaac's paintings with help from his Russian mentor; and Hiro struggles with his feelings for Yaeko.
Peter regains a forgotten power, learning about the virus attacking those with abilities in the process; Suresh, Matt, Nathan, Niki and Bob team up against the “nightmare man”; West discovers the man who kidnapped him as a child is Claire's father; and Hiro and Kensei's adventure takes a final twist.
A look back at the events immediately following the showdown with Sylar finds D.L. (Leonard Roberts) making the ultimate sacrifice for his family; Nathan paying a heavy toll for his heroic act; and Peter falling into the hands of The Company.
H.R.G. plans to run after thinking The Company found his family, but Claire has other ideas; Hiro returns to discover his father is dead; Matt struggles with his increasing mental powers; Suresh meets Elle and comes to a decision; the twins are tested as they travel with Sylar.
Peter goes to Texas with a plan to destroy the virus; Niki has bad news for Micah; Hiro targets his father's killer; Nathan finds out Peter survived; and Maya must choose between her brother and Sylar.
Peter finds himself in another showdown, this time in Texas, where he squares off against former friends thanks to Adam's confusing story about the Shanti virus. Elsewhere, Micah asks his mother to help him rescue Monica; Maya learns the truth about Sylar; and Elle tries to please her father.