A geneticist (Sendhil Ramamurthy) travels from India to New York to continue his dead father's research involving seemingly ordinary people with superpowers. Meanwhile, a male nurse (Milo Ventimiglia) dreams he can fly, and a high-school cheerleader (Hayden Panettiere) discovers that she's physically indestructible. At the same time, a sci-fi geek (Masi Oka) in Japan develops teleporting abilities. Santiago Cabrera, Tawny Cypress, Noah Gray-Cabey, Ali Larter, Adrian Pasdar.
Peter questions his own sanity; a confused Niki tries to cover her tracks; Mohinder opens up to a woman (Nora Zehetner) who knew his late father; Hiro discovers he's a character in a comic book written by Isaac; and Claire runs into trouble keeping her special powers under wraps. Jack Coleman. Agent Audrey Hanson: Clea DuVall.
Hiro sets about proving to Ando (James Kyson Lee) that he is meant to save the world; Matt is questioned by FBI agent Audrey Hanson (Clea DuVall) about suspected serial killer Sylar, who Mohinder learns had a connection with his dead father; Peter marvels at his newfound ability to fly, while Nathan makes a calculated move to keep the truth from the press. Also, Claire's attempt to maintain normalcy in her life proves difficult; Niki visits Micah's paternal grandmother; Isaac pushes Simone away.
Hiro takes a gamble in Las Vegas, at the same time that Nathan goes to Sin City to hit the mysterious Mr. Linderman up for a campaign contribution, and Niki discovers how her creditors plan to collect what she owes them. Also, Peter tells a skeptical Mohinder about his special powers; Claire deals with the aftermath of the traumatic bonfire incident; Matt is held against his will. Jack Coleman. Eden: Nora Zehetner. Ando: James Kyson Lee. Brody: Matt Lanter.
Hiro sends Peter a message from the future that involves Claire, and in the present, Hiro befriends Nathan after seeing him fly. Elsewhere, Claire and Brody (Matt Lanter) are taken to a hospital following the car crash; Matt's relationship with his wife, Janice (Lisa Lackey), benefits from his mind-reading abilities; and Niki wakes up confused after her one-night stand with Nathan. Horn-Rimmed Glasses: Jack Coleman. Ando: James Kyson Lee. Sandra Bennet: Ashley Crow.
Leonard Roberts joins the cast as D.L. Hawkins, Niki's fugitive husband, who has special powers that make it nearly impossible for authorities to track him down. Also, in Las Vegas, Hiro and Ando are made an offer they can't refuse; Claire hopes meeting her birth parents will lead to answers about her indestructibility; and Mohinder prepares to leave New York---and Eden---so that he can lay his dead father to rest in India. Nora Zehetner, Jack Coleman.
Simone seeks comfort from Peter following her father's death; Nathan receives campaign help from his wife, Heidi (Rena Sofer); Niki reveals her personal struggles to a friend; Matt finds himself immersed in the investigation of another bizarre murder, which Audrey (Clea DuVall) believes Sylar committed; Hiro unknowingly encounters another “hero”; Claire's tape is found...by her brother. Randall Bentley. Zach: Thomas Dekker. Janice Parkman: Lisa Lackey. Charles Deveaux: Richard Roundtree.
Mohinder considers his future while dreaming about his past; Hiro meets a waitress named Charlie (Jayma Mays), who demonstrates a knack for memorization; Matt uses his mind-reading abilities when interrogating the radioactive man (Matthew John Armstrong), and finds they have some things in common; Eden and Horn-Rimmed Glasses “help” Isaac with his paintings of the future; Claire focuses her attention on homecoming preparations, blissfully unaware of what the future has in store for her.
Claire's high-school homecoming turns into an event marked by tragedy and change. Also, Nathan locates the painting Peter needs to “save the cheerleader, save the world”; a boy with a special gift draws Mohinder back to his father's research; Micah makes a daring move to help Niki, while Jessica hunts for D.L.; and Ando (James Kyson Lee) waits for Hiro to return from his mission to rescue Charlie. Jayma Mays. Eden McCain: Nora Zehetner. Zach: Thomas Dekker. Nirad: Shishir Kurup.
The past is revisited as the clock turns back six months to when Chandra Suresh (Erick Avari) began contacting people who may possess extraordinary abilities, including a frustrated watchmaker (Zachary Quinto). At the same time, Nathan considers prosecuting his father's friend Linderman; Niki's life is complicated by a visit from her mostly absent dad; Hiro's mission to save Charlie doesn't go as expected; and Horn-Rimmed Glasses offers to give Eden's life purpose. Heidi: Rena Sofer.
The heroes struggle to come to terms with the Texas tragedy; more is learned about the nuclear bombing predicted in Isaac's painting; Matt and Audrey (Clea DuVall) pursue a new lead in their hunt for Sylar; Niki makes a difficult decision, which will allow her to keep her family safe. Eden: Nora Zehetner. Ando: James Kyson Lee. Zach: Thomas Dekker. The Haitian: Jimmy Jean-Louis.
A new hero (Christopher Eccleston) arrives on the scene; Nathan and Simone try to help Peter, who has been comatose for two weeks; Hiro goes on a quest to find the samurai sword seen in Isaac's painting. Also, Horn-Rimmed Glasses concentrates his efforts on taking care of Sylar (Zachary Quinto); Claire struggles to come to terms with the fact that she has been living a lie; Niki is held and questioned by police. Zach: Thomas Dekker.
Hiro is abducted by mysterious thugs before he can leave New York; Claire decides to search for her birth parents; D.L. works to deal with his family duties; and Claude reluctantly agrees to help Peter with his powers. George Takei, Jessalyn Gilsig. Claude: Christopher Eccleston.
Hiro tries to explain his new life direction to his unsympathetic father and sister; Niki tries to connect with D.L. and Micah; Peter gets another lesson in harnessing his power; and Claire's search for her birth mother leads her to a Texas trailer park. George Takei, Saemi Nakamura, Jessalyn Gilsig. Claude: Christopher Eccleston.
Peter is disappointed by a betrayal; Claire can't contain her anger toward her father; Matt loses control when radioactive refugee Ted Sprague (Matthew John Armstrong) shows up with a new hero (Stana Katic) who has “wireless” mental powers.
Nathan meets Linderman in person just before the election; Hiro goes for the sword again with dire consequences; Suresh makes a breakthrough on “the list”; another person with powers, Candice Wilmer (Missy Peregrym), shows up.
Hiro is disturbed by the grim future he discovers where those with special abilities are hunted and considered threats to society. He attempts to return to his own time, but is caught up in a battle that involves a host of new and oddly familiar faces.
Hiro and Ando are even more determined to save the world after seeing the grim future; Nathan takes steps to win the election; Thompson (Eric Roberts) brings someone new into the organization; and Sylar visits his mom (Ellen Greene).
Nathan weighs his mother's advice against plans by Linderman; Hiro gets some family information as he prepares to face Sylar; Peter and Ted try to leave New York to avoid the explosion. George Takei and Eric Roberts guest star.