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Greys Anatomy, Katherine Heigl, Patrick Dempsey
Grey's Anatomy - Season 5 - "What A Difference a Day Makes" - Katherine Heigl, Patrick Dempsey
courtesy Scott Garfield/ABC
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Cast & Details

Premiered: March 27, 2005, on ABC
Rating: TV-14
User Rating: (2,398 ratings)
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Premise: Surgical residents at a Seattle teaching hospital hone their bedside manners on and off the job in this medical drama, which parlayed a cushy initial time slot (post-'Desperate Housewives') and a hefty dollop of sex and romance into immediate success. Indeed, in the opener, intern Meredith Grey sleeps with attending Derek ('McDreamy') Shepherd the night before starting work at Seattle Grace and discovers the next day that he's her boss. Their romantic ups and downs became the series' keystone.

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Grace under Pressure: Grey's Anatomy Uncovered
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From Cambridge Scholars Publishing (Hardcover)
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Grey's Anatomy: The Complete Fourth Season [Blu-ray]
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