Season 2, Episode 11 Owner of a Lonely Heart

First Aired: December 4, 2005

The quints present a number of challenges, and so does their mother (Margaret Welsh), who's depressed. The sickest infant is assigned to Izzie, who's taught a painful lesson in doctoring from Addison. Izzie is also seething at Alex, who's depressed because of a medical mistake he made. Meanwhile, George uses leeches to treat an avid outdoorsman with skin cancer; and a prisoner (Rosanna Arquette) swallows four razor blades to get a “vacation” from prison.

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Guest Cast