Ivy tricks Teddy into joining her family on a road trip to Las Vegas, N.M. Meanwhile, Amy's feelings are hurt when she learns that Gabe is secretly playing league baseball because he doesn't want her to embarrass him; and Bert Doogan and Mrs. Dobbs announce they are getting married and want the wedding to take place at the Duncan house.
Bob and Amy attend a pest control association's annual dinner and dance, and Beau asks Teddy to be his date at the same event. Meanwhile, Gabe scores tickets to the first showing of a hot new movie for an upcoming date.
Amy goes overboard to celebrate Charlie's birthday; Teddy goes to work at Bob's extermination business and meets a young exterminator; Gabe is sent home from school for accidentally getting into a fight.
Teddy uncovers mysterious clues that lead her to suspect that someone at school is out to get her. Meanwhile, Amy and Bob become convinced that Deedee Dooley is teaching Charlie bad behavior; and Gabe tries to prevent his report card from being mailed home.
Teddy experiences weird dreams when she struggles to find a topic for her college essay. Meanwhile, Bob and PJ go on a road trip to see one of Bob's favorite bands; and Gabe is involved in a prank that goes bad.
Amy films Teddy's alumni interview for her Yale application as part of the Mama Bird segment for "Good Morning Denver," but things don't go as planned. Meanwhile, Gabe gets PJ to distract Mrs. Dabney so he can hang out with her cute granddaughter.
Teddy decides to stop seeing Spencer, when he calls from college and tells her he is going out on a date. Meanwhile, Bob tries to trick Amy into loving a new couch he bought against her wishes; and PJ endures a rough first day at cooking school.
The fourth season begins with the Duncans planning to build their dream house after their home is devastated by termites. But Teddy is visited in a dream by Kermit the Frog, Miss Piggy, Fozzie Bear and Animal, who tell her that the old home is her real dream house.