In the series finale, Simon recovers from his stab wounds and Nick discovers how Simon has been controlling Nola. Meanwhile, Lisa starts writing a tell-all book about the Darlings, and Nola goes to China to rescue her brother.
Karen and Nick profess their love for each other, and she reveals she's carrying Simon's baby. Elsewhere, Nola fears that Simon may be setting a trap for Jeremy; Andrea throws Brian out; and Congressman Whatley's wife makes a pass at Patrick.
Nick borrows the Darlings' jet to retrieve Kiki from Maryland, and Karen and Brian accompany him, each needing to attend to personal matters. Meanwhile, Tripp wants Patrick to convince a congressman (John Schneider) to reverse his standing on biofuel.
While the Darlings are away celebrating Thanksgiving, Clark the chauffeur must deal with a persistent and seductive reporter (Rena Sofer), so he gives her his version of several Darling family happenings. Elsewhere, Letitia hosts a fashion show at the mansion, and one of the attendees (Donna Mills) has some unkind words for her.
The Darlings cope with the impact of a shooting spree that resulted in a death, a coma patient and an amnesia victim; Nick and Lisa try to settle custody arrangements regarding Kiki; and Brian's relationship with Andrea leads him back to the pulpit.
Patrick invites Carmelita to his inauguration and faces a possible public accusation of murder if Chase makes good on his threats. Meanwhile, Jeremy figures out why Simon has a hold on Nola; Brian makes promises to God as Andrea's health suffers; and a dangerous intruder confronts Karen when she stops by Nick's place.
Karen's wedding to Simon nears, and Lisa plans on bringing Jeremy to the nuptials to provoke jealousy in Nick. Elsewhere, Patrick gives Jeremy a job, despite Nola's objections; Brian bonds with Andrea; and Letitia wants houseguest Wrenn to leave after she sees Tripp is growing fond of her.
Letitia hits a bicyclist with her car and invites her to the mansion to recuperate. Meanwhile, Lisa and Karen have a confrontation over Nick; Nola's actions in her new position please Patrick; and Andrea chooses not to participate in a medical trial that could help her.
Nick discovers a secret about Nola and learns something surprising about his wife. Meanwhile, Karen wants Nick to inform Tripp of her impending nuptials; Tripp has an opinion about whom Patrick should select as his chief of staff; and Brian and Andrea hear shocking news from a doctor. Good Charlotte's Joel Madden guest stars as himself.
Patrick must deal with Tripp opposing his plan to take his relationship with Carmelita public and Ellen's brother demanding the truth about his sister's death. Meanwhile, Nick and Lisa attend couples therapy; Jeremy tries to get Letitia's house-arrest restrictions lessened; and Brian Jr. goes missing.
As Nick prepares to defend Letitia, he is not pleased to see his estranged mother's name on the prosecutor's witness list. Meanwhile, Patrick wants to tell the truth about Ellen's death but Tripp objects; and Brian heads to Brazil to kidnap his son. Dan Rather appears as a debate moderator, and the Weepies perform.
The Darlings must deal with the aftermath of a fire and a death as well as an arrest in the case of the murder of Dutch George. Meanwhile, Brian talks to Tripp about naming a successor, and Jeremy learns what Nola really does for a living. Musician Kenny G appears as himself.
In the second-season premiere, Tripp and Letitia throw Nick an elaborate birthday party on a yacht. Meanwhile, Brian reunites with his son, and Jeremy tells Nola Lyons (Lucy Liu) about his feelings for Lisa. Later, tragedy strikes when a death occurs, followed by an arrest.