Corcoran suffers a shocking loss; Freeman goes beyond his role as a doctor to help fight the illness that is sweeping through Five Points; and Morehouse fights to ensure that part of his tumultuous past remains hidden.
Corcoran hits a dead end in his investigation; Freeman fights to contain the outbreak of a mysterious illness in Five Points; Elizabeth tries to help with Morehouse's business; and Donovan connives with Eva Heissen.
The search for a cop killer is derailed when Annie Reilly creates a rift in the Corcoran home. Meanwhile, Eva discovers an unlikely ally in Donovan; Elizabeth soothes her troubled conscience by helping the Freemans; and Maguire crosses paths with some of his old friends.
Corcoran closes in on the suspects responsible for kidnapping and murdering young Five Points men. Meanwhile, Francis Maguire embraces his new position in the underworld; and Robert and Elizabeth exchange vows and experience a most unexpected evening.
More boys disappear and are killed, and Donovan uses unseemly tactics to keep the murders out of the press. Meanwhile, Sara dines with Frederick Douglass at the Morehouse mansion and is forced to confront her past.
The second season begins with Corcoran reporting to a new ward leader and investigating the disappearance of several missing boys. Meanwhile, Freeman is presented with a tough choice that could cause a rift in his marriage; and Maguire awaits his fate in prison.