Season 2 opens with Jenny Lee's birthday. The next day she takes on a new patient who's involved in an abusive relationship. In other events, Trixie and Sister Evangelina board a Swedish cargo ship to care for the captain's daughter, who's about to have her first baby.
Cynthia comes under scrutiny from the community and police when a newborn baby she delivered dies. The incident also leads her to question her abilities. In other events, Chummy decides to pursue her dream and Jimmy reenters Jenny's life.
Jenny is transferred to a short-staffed hospital, where she finds herself assigned to the male surgical ward and working with an intimidating surgeon. Meanwhile, in Jenny's absence, new arrival Jane helps out at Nonnatus House; and the staff deal with identical twins when one becomes pregnant.
The community prepares for the annual summer fête, which is slated to feature a baby show with a celebrity judge. In other events, Jenny meets an impoverished mother of eight who fears that she may soon have another mouth to feed.
Cynthia helps a woman who's being bullied by her husband while Jenny cares for a black mother-to-be who's a victim of racial prejudice. In other events, Fred teachers the midwives how to ride a scooter when Nonnatus House comes into possession of one; and Chummy and Peter return from Sierra Leone.
In the Season 2 finale, Chummy and PC Noakes face several challenges; Fred is thrilled when his daughter and her infant son arrive for a visit; Jenny meets a potential suitor; and Nonnatus House is targeted for demolition.