As Christmas approaches, Bull is amused when he meets a 9-year-old girl who wants to hire him to help her divorce her parents, but he's shocked when a judge appoints him her temporary guardian. Also, Marissa discovers disturbing information about her boyfriend, Kyle.
As Thanksgiving approaches, Bull releases his team to enjoy the holiday with their families, only to find himself working a case solo when he agrees to help a boxer who is being tried for murder. Also, Chunk makes a major personal decision at his family's Thanksgiving dinner, while Marissa's dinner with Kyle is abruptly cancelled when he is mugged.
Bull agrees to help the parents of a former employee sue a drug company when their son commits suicide during a drug trial. However, the task is complicated when the company brings in their own trial scientist.
The D.A's office asks Bull to assist in its prosecution of a fraternity after a pledge accidentally drowns during a hazing incident, but his efforts are threatened when the students close ranks to stonewall him.
Season 2 begins with Bull squaring off with his on-again, off-again romantic interest when he joins the district attorney's case against a woman who claims she killed her billionaire husband in self-defense. Meanwhile, Chuck makes a decision about his future.