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Cesare is brought to La Mancha and goes on trial before the Inquisition while Lucrezia must use extreme measures to save her marriage.
Lucrezia meets her new family with mixed results while at home a malaria outbreak has historic consequences for the Borgias.
Outside of Italy rebellion stirs and the Cardinals fear they'll lose their power while plans begin for Lucrezia's next marriage.
When one of his commanders captures a city without authorisation Cesare must appease a ruler. Lucrezia's son suffers a potentially mortal fall.
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- Premiered: October 10, 2011
- Rating: None