Philadelphia surgeon Megan Hunt (Dana Delany) changes careers to become a medical examiner when an accident leaves her unable to operate. In the opener, a body is found in the Schuylkill River, and Hunt's work style proves polarizing to colleagues. Hunt also tries to repair her relationship with her daughter by coming up with the perfect present for her 12th birthday.
A young interracial couple is found shot and killed in their car and Megan finds evidence that contradicts police officers' theory of the crime. Also, Megan tries to reconnect with her daughter, and Peter warns her not to push too hard.
A severed hand and foot are found, and the team tries to reassemble the victim. Elsewhere, Megan's daughter asks to film her at work for a social-studies project, and what she learns in the process substantially changes her opinion of her mother.
The identical twin (Christina Hendricks) of a beautiful corpse piques Ethan's interest. Meanwhile, a patient who died after surgery at Megan's old hospital leads Megan to suspect the patient's doctor (Marc Blucas) of malpractice or murder. She starts asking questions, and hospital personnel close ranks.
A stabbing rocks the Philadelphia suburbs, and makes Megan recall her father's death. Meanwhile, Megan pulls car-pool duty with the hard-to-impress Lacey and her girlfriends and Kate consults in a pro bono case with Megan's ex-husband.
A philanthropic socialite dies, and Megan suspects foul play even though the woman had a terminal illness. Megan's investigation holds up the funeral plans, upsetting the deceased's mother, and Kate's personal life interrupts the investigation.