D.L. Hughley hosts the fifth annual celebration of the year's biggest people, moments and stories. Slated performers include Fergie, the Killers and the Fray. Also set to appear: Justin Timberlake; Eva Longoria; Kiefer Sutherland; Joey Lawrence; Ice-T; Lance Bass; Mario Lopez; Danny Bonaduce; Katharine McPhee; Hal Sparks; Andrew Dice Clay; ANT; Kennedy; and "Weird Al" Yankovic. Flavor Flav is a backstage correspondent.