Thirteen houseguests try to avoid eviction in order to win the grand prize of $500,000. The fifth edition is dubbed `Project: DNA' for two reasons. The first is `Do Not Assume,' a premise meaning the players shouldn't assume anything. The other reason is that two of the houseguests are related to one another, but they don't know it. Jennifer Dedmon and Michael Ellis share the same father, but they have never met. Michael also has never met his real dad.