After Astro regains his memory and returns home to Dr. O'Shay, Dr. Tenma vows revenge and stages a ferocious high-tech attack on the Ministry of Science. Can Astro reason with him in time to save the Ministry?
The conflict between humans and robots continues as both sides prepare for a final massive battle. Although Astro is close to negotiating a peace settlement, Drake is determined to destroy all of the robots.
As the first step in his robot revolution, the Blue Knight establishes a new robot nation in the Arctic called Robotonia. With human anti-robot forces determined to find and destroy Robotonia, Astro is caught in the middle trying to make peace on both sides.
Hunters from the future are stealing animal DNA from different time periods in order to enhance their own powers. When Zoran is accidentally caught in the hunters' time machine and transported back to the Stone Age, it's up to Astro to rescue her.
Zoran is jealous of her big brother's super-hero status, so she joins Detective Wally Kisagari to try and solve a strange case involving a bird-like phantom that has been appearing throughout the city.
Astro's new human friend Matthew loves robots so much that he dresses up in scrap metal and pretends that he is a robot. But when Matthew tries to use his "robot" powers to rescue his mother from a space-shuttle accident, it's up to Astro to save them.