After 9/11, heroin kingpins and terrorists forge an alliance as Afghanistan becomes a narco-state. Meanwhile, El Chapo takes it on the lam; Big Pharma becomes the new big drug lord as Americans get addicted to prescription drugs.
Cocaine makes its way to America from secret airports, enriching violent cartel bosses, and an infamous "black widow," and the CIA's shadow wars have unintended consequences. President Reagan cracks down as crack invades the U.S.
An exploration of the recreational-drug business and its impact on the U.S. begins with a look at covert Cold War operations that empowered a generation of drug traffickers and reveals details of secret CIA LSD experiments, and President Nixon's crackdown and declaration of a war on drugs.