Michael's high-school girlfriend arrives at Holy Neuro with a grave condition, and he has trouble accepting the limits of what he can do to help her. Meanwhile, Zeke learns that his best friend is battling a cancer relapse.
A pampered pop star arrives at Holt Neuro with atypical symptoms similar to those experienced by a young girl at the clinic. The doctors at both medical facilities then work together to try and find an underlying connection.
Kate and Michael team up to help a clinic patient who contracted a deadly virus. Meanwhile, Michael treats an anxious bride with headaches and observes that her mother (Faith Prince) is showing signs of a grave illness.
The heinous criminal actions of a brain-tumor patient (John Benjamin Hickey) weigh on Michael as he makes a choice about saving the man's life. Meanwhile, a seemingly disoriented female firefighter (Mamie Gummer) is examined at Holt Neuro.
Michael is surprised to see an ex-football star whom he once treated now getting help at the clinic because he's homeless. Meanwhile, Michael deals with a case of post-traumatic stress disorder at his practice.
A neuropsychiatrist (Eriq La Salle) impresses Michael by diagnosing a patient based on her body language, so Michael invites him to join his practice. Meanwhile, Michael faces a situation with a patient that could jeopardize his practice.