After hosting Late Night with Conan O'Brien from 1993 to 2009 and The Tonight Show from 2009 to 2010, funnyman Conan O'Brien bursts back to television with this newly minted late-night talk show. Although the series features the usual fare — interview segments, musical guests and comedy bits — the string-dancing, flame-haired talk-show vet is expected to punch up the proceedings with his wildly irreverent comedy flair. Longtime Conan collaborators also return: Andy Richter serves as the series sidekick, and Jimmy Vivino, former associate music director of Conan's previous talk shows, conducts the house band. Tonight's opener features interview guests Seth Rogen and Lea Michele, plus music performer Jack White. — Dean Maurer
Read on for previews of Matt Lauer Reports, 90210, Cake Boss, House, A Fighting Chance and The Big C.