Premiered: September 17, 1996, on ABC
Premise: New York City's unflappable, charismatic deputy mayor makes his clueless boss look good in this sharply written, well-played sitcom. Parkinson's disease forced Michael J. Fox to leave the show in 2000, the year he won the Emmy as Outstanding Lead Actor in a Comedy Series. He was replaced by Charlie Sheen, who stayed with the show until its end in 2002.