Venus Williams by Chris McGrath/Getty Images; Serena Williams by Al Bello/Getty Images
As expected, the Williams Sisters are set to meet in the U.S. Open quarterfinals Wednesday. Following their fourth-round victories on Labor Day, Venus and Serena will play under the lights at Arthur Ashe Stadium (Sept. 3, 7 pm/ET, USA Network).

Fourth-seeded Serena advanced to the quarters with a straight-set win over France's Severine Bremond. No. 7 Venus had an equally breezy triumph against Agnieszka Radwanska of Poland.

This will be the 17th time the Williams have played as pros, and will break an 8-8 series tie. In July, Venus defeated Serena in the Wimbledon final. Since then they teamed up to win the Olympic doubles gold in Beijing.

Of the idea of playing her big sister in the quarterfinals, rather than the championship match, Serena told USA's Michael Barkann: "It sucks [but] at least one of us will make it to the semifinals." When asked by Barkann what Venus does best, Serena replied: "She runs so fast, she serves so hard, she volleys incredible. I actually want to volley like her. That's why I play doubles with her: she's the best."