Jordana Spiro, The Mob Doctor

Meredith Grey she ain't! Forget what you know about Spiro from My Boys. As the titular Mob Doctor, young surgeon Dr. Grace Devlin juggles her budding professional career and her side job — paying off her brother's gambling debts by doing medical work for the Chicago mafia. This will be the actress' second brush with danger: She did a guest arc on Dexter last season.