Meredith Grey (Ellen Pompeo)
Where Were We? Meredith was one of the Stranded Six, who crash-landed in the forest. Before they left, she had accepted a job offer at Brigham Women's Hospital in Boston. She was unfortunately searching for Derek when her sister Lexie met her maker in the crash.
What's Next? Following the loss of her sister, Meredith will take on a surprising new role as, essentially, the new Nazi — complete with a fancy nickname! "She's definitely angry at the beginning of the season," Pompeo says. "She's angry about all the stuff that happened, so she's teaching her interns and she's really mean to them. It's an homage to the first Dr. Grey, Meredith's mother, who is the first bitch surgeon, so I get to channel Kate Burton and be mean." She'll also be struggling with keeping the team of Seattle Grace docs intact. "She wants everyone else to stay together and is trying to rally for everyone to stick around," she adds. Look for Mer to stay in touch with twisted sister Cristina in very interesting ways.