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24. "Flight," Grey's Anatomy
Just when you think Shonda Rhimes can't up the shocking-finale ante anymore when it comes to shocking finales, she leaves Meredith, Derek, Cristina, Arizona, Lexie and Mark stranded on a mountainside after a plane crash. Their traumatizing ordeal is all the more devastating as the docs hopelessly stand by as Lexie, crushed by a section of the aircraft, dies. Even worse? The docs are not rescued by the end of the episode. (RIP Lexie, Mark and Arizona's leg).